CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial
Identifieur interne : 005450 ( Main/Exploration ); précédent : 005449; suivant : 005451CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial
Auteurs : J. Alexandre [France] ; C. Brown [Australie] ; D. Coeffic [France] ; N. Raban [France] ; J. Pfisterer [Allemagne] ; J. M Enp [Finlande] ; H. Chalchal ; B. Fitzharris [Nouvelle-Zélande] ; B. Volgger [Autriche] ; I. Vergote [Belgique] ; C. Pisano [Italie] ; A. Ferrero [Italie] ; E. Pujade-Lauraine [France]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2012.
Abstract
CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.
In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.
In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD
CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.
Url:
DOI: 10.1038/bjc.2011.593
PubMed: 22240800
PubMed Central: 3322951
Affiliations:
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Alexandre</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Département d'Oncologie Médicale, Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre</institution>, site Hôtel-Dieu, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brown, C" sort="Brown, C" uniqKey="Brown C" first="C" last="Brown">C. Brown</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>NHMRC Clinical Trials Centre</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coeffic, D" sort="Coeffic, D" uniqKey="Coeffic D" first="D" last="Coeffic">D. Coeffic</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Medical Oncology Department, Hôpital des Diaconesses</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raban, N" sort="Raban, N" uniqKey="Raban N" first="N" last="Raban">N. Raban</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Medical Oncology, University Hospital of Milétrie</institution>, Poitiers,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfisterer, J" sort="Pfisterer, J" uniqKey="Pfisterer J" first="J" last="Pfisterer">J. Pfisterer</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Gynecology, Staedtisches Klinikum Solingen</institution>, Solingen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Enp, J" sort="M Enp, J" uniqKey="M Enp J" first="J" last="M Enp">J. M Enp</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Obstetrics and Gynecology, University of Tampere and Tampere University Hospital</institution>, Tampere,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chalchal, H" sort="Chalchal, H" uniqKey="Chalchal H" first="H" last="Chalchal">H. Chalchal</name><affiliation><nlm:aff id="aff7"><institution>Department of Medicine, University of Saskatchewan. Allan Blair Cancer Centre</institution>, Regina,<country>Saskatchewan</country></nlm:aff><wicri:noCountry code="nlm country">Saskatchewan</wicri:noCountry></affiliation></author><author><name sortKey="Fitzharris, B" sort="Fitzharris, B" uniqKey="Fitzharris B" first="B" last="Fitzharris">B. Fitzharris</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Christchurch Hospital</institution>, Christchurch,<country>New Zealand</country></nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volgger, B" sort="Volgger, B" uniqKey="Volgger B" first="B" last="Volgger">B. Volgger</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Obstetrics and Gynecology, University Hospital Innsbruck</institution>, Innsbruck,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>University Hospital Leuven, Leuven Cancer Institute and Department of Gynaecological Oncology</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pisano, C" sort="Pisano, C" uniqKey="Pisano C" first="C" last="Pisano">C. Pisano</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Division of Medical Oncology, Uro-Gynecological Department, National Cancer Institute</institution>, Naples,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A" last="Ferrero">A. Ferrero</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Academic Division of Gynecologic Oncology, Mauriziano Hospital</institution>, Torino,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Département d'Oncologie Médicale, Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre</institution>, site Hôtel-Dieu, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.</p></sec><sec><title>Methods:</title><p>In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.</p></sec><sec><title>Results:</title><p>In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD <italic>vs</italic> C-P in progression-free survival was not influenced by type of first progression (hazard ratio 0.85 (95% confidence interval (CI): 0.66–1.10) and 0.84 (95% CI: 0.72–0.98) for CA-125 and RECIST, respectively). In patients with CA-125 first progression who subsequently progressed radiologically, a delay of 2.3 months was observed between the two progression types. After CA-125 first progression, median time to new treatment was 2.0 months. In all, 81%of the patients with CA-125 or radiological first progression and 60% with symptomatic first progression received subsequent treatment.</p></sec><sec><title>Conclusion:</title><p>CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bast, Rc" uniqKey="Bast R">RC Bast</name></author><author><name sortKey="Thigpen, Jt" uniqKey="Thigpen J">JT Thigpen</name></author><author><name sortKey="Arbuck, Sg" uniqKey="Arbuck S">SG Arbuck</name></author><author><name sortKey="Basen Engquist, K" uniqKey="Basen Engquist K">K Basen-Engquist</name></author><author><name sortKey="Burke, Lb" uniqKey="Burke L">LB Burke</name></author><author><name sortKey="Freedman, R" uniqKey="Freedman R">R Freedman</name></author><author><name sortKey="Horning, Sj" uniqKey="Horning S">SJ Horning</name></author><author><name sortKey="Ozols, R" uniqKey="Ozols R">R Ozols</name></author><author><name sortKey="Rustin, Gj" uniqKey="Rustin G">GJ Rustin</name></author><author><name sortKey="Spriggs, D" uniqKey="Spriggs D">D Spriggs</name></author><author><name 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sortKey="Pujade Lauraine, E" uniqKey="Pujade Lauraine E">E Pujade-Lauraine</name></author><author><name sortKey="Parmar, Mk" uniqKey="Parmar M">MK Parmar</name></author><author><name sortKey="Friedlander, M" uniqKey="Friedlander M">M Friedlander</name></author><author><name sortKey="Jakobsen, A" uniqKey="Jakobsen A">A Jakobsen</name></author><author><name sortKey="Vermorken, Jb" uniqKey="Vermorken J">JB Vermorken</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Finlande</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li></country></list><tree><noCountry><name sortKey="Chalchal, H" sort="Chalchal, H" uniqKey="Chalchal H" first="H" last="Chalchal">H. Chalchal</name></noCountry><country name="France"><noRegion><name sortKey="Alexandre, J" sort="Alexandre, J" uniqKey="Alexandre J" first="J" last="Alexandre">J. Alexandre</name></noRegion><name sortKey="Coeffic, D" sort="Coeffic, D" uniqKey="Coeffic D" first="D" last="Coeffic">D. Coeffic</name><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name><name sortKey="Raban, N" sort="Raban, N" uniqKey="Raban N" first="N" last="Raban">N. Raban</name></country><country name="Australie"><noRegion><name sortKey="Brown, C" sort="Brown, C" uniqKey="Brown C" first="C" last="Brown">C. Brown</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Pfisterer, J" sort="Pfisterer, J" uniqKey="Pfisterer J" first="J" last="Pfisterer">J. Pfisterer</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="M Enp, J" sort="M Enp, J" uniqKey="M Enp J" first="J" last="M Enp">J. M Enp</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Fitzharris, B" sort="Fitzharris, B" uniqKey="Fitzharris B" first="B" last="Fitzharris">B. Fitzharris</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Volgger, B" sort="Volgger, B" uniqKey="Volgger B" first="B" last="Volgger">B. Volgger</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Pisano, C" sort="Pisano, C" uniqKey="Pisano C" first="C" last="Pisano">C. Pisano</name></noRegion><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A" last="Ferrero">A. Ferrero</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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